Using the Lasso to simultaneously identify the covariate and variance-covariance structures of nonlinear mixed-effects models
نویسنده
چکیده
Remifentanil is a synthetic opioid with ultrafast elimination. Its pharmacokinetics after a one-minute infusion in children (age range 5 days 17 years) have been described by Kinder Ross et al. using modelindependent analysis [1]. The first objective of the present study was to obtain a compartmental model of remifentanil pharmacokinetics with the possible inclusion of covariates age and weight.
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تاریخ انتشار 2006